Modelling of the dose response for nephrotoxicity in preclinical targeted radionuclide therapy with 161Tb and 177Lu radiolabeled peptides

Position: PhD position

Institution: Belgian Nuclear Research Centre (SCK CEN)

Location: Mol, Belgium

Application closes at: Mar 31st, 2021 16:00

URL: https://academy.sckcen.be/en/Your_thesis_internship/AllTopics/Modelling-of-the-dose-response-for-nephrotoxicity-in-preclinical-targeted-radionuclide-therapy-with-161Tb-and-177Lu-radiolabeled-peptides-2788

Modelling of the dose response for nephrotoxicity in preclinical targeted radionuclide therapy with 161Tb and 177Lu radiolabeled peptides

Radiation-induced kidney toxicity (nephrotoxicity) has shown to be a dose-limiting factor during peptide receptor radionuclide therapy using beta-emitting radiolabeled somatostatin analogs 90Y-DOTATOC and 177Lu-DOTATATE for the treatment of somatostatin receptor-positive neuroendocrine tumors. Biophysical models to predict endpoints of renal damage based on absorbed dose and radiobiological parameters are highly desired to support the implementation of individual treatment evaluation and planning in clinical targeted radionuclide therapy (TRNT).

A subject that is key for a better understanding and modelling of nephrotoxicity in TRNT and that requires further investigation is the influence of dose heterogeneity in the biological response of the kidney.

In this PhD project, the aim is to build a simulation framework for better modelling of the dose-response for kidney toxicity of targeted radionuclide therapy with beta-emitting radioligands in preclinical in vivo settings.

More information about the PhD topic and the application procedure can be found in the SCK CEN website.

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